Dissemination of results
Publications in which the financial support of the project was acknowledged:
Research articles:
- Petre B.A., Ulrich M., Stumbaum M., Bernevic ., Moise A., Döring G., Przybylski M. (2012), When is Mass Spectrometry Combined with Affinity Approaches Essential? A Case Study of Tyrosine Nitration in Proteins, J. Am. Soc. Mass Spectrom, 23(11): 1831-1840. IF – 3.592
- Schreier V. N., Pethő L, Orbán E., Marquardt A., Petre B.A., Mező G. and Manea M. (2014), Protein expression profile of HT-29 human colon cancer cells after treatment with a cytotoxic daunorubicin-GnRH-III derivative bioconjugate, PLoS ONE, 9(4):e94041. IF – 3.234
Book chapters:
- Petre, B.A. (2014), Affinity – mass spectrometry approaches for elucidating structures and interactions of protein – ligand complexes in Advances in experimental medicine and biology – Springer, 01/2014; 806:129-151. DOI: 10.1007/978-3-319-06068-2_7. IF – 1.953
- Vrinceanu N., Petre B.A., Hristodor C. M., Popovici E., Pui A., Coman D. and Tanasa D. (2013), Zinc Oxide — Linen Fibrous Composites: Morphological, Structural, Chemical, Humidity Adsorptive and Thermal Barrier Attributes in “Modern Surface Engineering Treatments”, Ed. Aliofkhazraei M., Intec – ISBN 978-953-51-1149-8, page 21-44.
Supplemental results
In addition, the infrastructure acquired by the current project was used to complete the experimental part of one PhD thesis. Laura Ion, PhD student and member of the research team was coordinated in part by Dr. Brindusa Petre, the director of the project.
PhD thesis: Laura Ion, “Compounds with peptide bonds and their biomedical applications” – examination date November 27th 2015.
Participation at Scientific Events
2014
47. Jahrestagung der Deutschen Gesellschaft für Massenspektrometrie (DGMS), Frankfurt, DE (2 – 5 March 2014)
Brînduşa-Alina Petre, Claudia Andrieș, Mihaela Stumbaum, Bogdan Bernevic, Martina Ulrich, Gerd Doering, Gabi Drochioiu, Michael Przybylski, “When is Mass Spectrometry Combined with Affinity Approaches Essential? A Case Study of Tyrosine Nitration in Proteins” – Oral Presentation
Laura Ion, Claudia Cozma, Claudia Andrieș , Michael Przybylski and Brîndușa-Alina Petre, “Specific lysosomal diagnostic for MPS II / MPS VI patients by fluorimetry and mass spectrometry” – Poster
Claudia Andries, Laura Ion, Brian Gau, Michael Gross, Gabi Drochioiu, Brînduşa Alina Petre, “Molecular characterization of neuronal protein aggregates by mass spectrometry-based footprinting methods” – Poster
Anniversary Symposium „Michael Przybylski’s contribution to mass spectrometry in life sciences“Konstanz, DE (April 25th – 26th 2014)
Brindusa-Alina Petre, Claudia Andries, Laura Ion, Lucian Hritcu, Brian Gau, Michael Gross, “Molecular characterization of neuronal Abeta aggregates by Mass spectrometry-based footprinting methods” – Oral presentation
Colloquium “20 years of partnership between the University of Konstanz and “Al. I. Cuza” University of Iasi” at the Department of Chemistry, University of Konstanz, , DE
Brindusa-Alina Petre, Mihaela Stumbaum, Bogdan Bernevic, Martina Ulrich, Gerd Doering, Andrieş Claudia, Laura Ion3, and Michael Przybylski, “When is Mass Spectrometry Combined with Affinity Approaches Essential? A Case Study of Tyrosine Nitration in Proteins” – Oral Presentation
a XXXIII-a Conferinţă Naţională de Chimie, Căciulata, Ro (1 – 3 Octombrie 2014)
Laura Ion, Mihaela Stumbaum, Michael Przybylski, Gabi Drochioiu and Brîndușa Alina Petre, “Binding Affinities Studies Of Nitrated Model Peptides To Anti-3-Nitrotyrosine Antibody” – Poster
Claudia Andrieș, Gabi Drochioiu, Michael Przybylski and Brîndușa Alina Petre, “Eosinophil Peroxidise Peptide Mapping by Mass Spectrometry” – Poster
3eme Colloque Franco-Roumain de Chimie Médicinale”, Iași, RO (30-31 Octombrie 2014)
Laura Ion, Claudia Andrieș, Lucian Hriscu, Brian Gau, Michael Gross, Brindusa-Alina Petre, “Mass spectrometric based approaches for studying aggregation of ß-amyloid peptide” – Oral Presentation
Laura Ion, Claudia Andrieș, Ștefan Slamnoiu, Michael Przybylski, Gabi Drochioiu and Brîndușa Alina Petre, “Pathophysiological oxidative protein modifications: nitration versus hydroxylation of tyrosine” – poster
Conferința Facultății de Chimie cu ocazia Zilelor Universității, Iași, RO (31-1 Octombrie 2014)
Laura Ion, Claudia Cozma, Claudia Andrieș, Gabi Drochioiu, Michael Przybylski and Brîndușa-Alina Petre, “Lysosomal Storage Disease. Characterization and Diagnostics of MPS II and MPS VI” – Oral Presentation
Claudia Andrieș, Gabi Drochioiu, Michael Przybylski, Bîndușa Alina Petre, “Molecular characterization of eosinophil peroxidase peptide by mass spectrometry” – Oral Presentation
Affinity-Mass Spectrometry in Life Sciences Diagnostics & Therapy Development of Lysosomal Diseases, Rüsselsheim, DE (24-25 Noiembrie 2014)
Brîndușa Alina Petre, Mihaela Stumbaum, Martina Ulrich, Gerd Doering, Andrieş Claudia, Laura Ion, and Michael Przybylski, “Elucidation of Protein Oxidative Modifications Using Affinity- Mass Spectrometry: A Case Study of Tyrosine Nitration in Proteins” – Oral presentation
Laura Ion, Claudia Cozma, Claudia Andrieș, Michael Przybylski and Brînduşa – Alina Petre, “Specific lysosomal diagnostic for MPS II / MPS VI patients by fluorimetry and mass spectrometry” – Poster
2013
46. Jahrestagung der Deutschen Gesellschaft für Massenspektrometrie (DGMS), Berlin, DE (10 – 13 March 2013)
Brînduşa-Alina Petre, Claudia Andrieş, Gabi Drochioiu, Michael Przybylski, Martina Ulrich and Gerd Doering, “Molecular characterization of neuronal protein aggregates by Mass spectrometry-based footprinting methods” – Poster
Laura Ion, Claudia Andrieș, Mihaela Stumbaum, Michael Przybylski, Brîndușa Alina Petre, “Mass spectrometric based methods for rigorous charaterization of antibody-antigen interaction” – Poster
11th Conference on Colloid and Surface Chemistry, Iasi, RO (9-11 May 2013)
Laura Ion, Brian Gau, Michael Gross, Manuela Murariu, Brîndușa Alina Petre, “Molecular characterization of neuronal protein aggregates by Mass spectrometry-based footprinting methods” – Short communication
Laura Ion, Claudia Andries, Mihaela Stumbaum, Michael Przybylski, Brîndusa Alina Petre, “Mass spectrometric based methods for rigorous characterization of antibody-antigen interaction” – Poster.
7th Summer Course for Mass Spectrometry in Biotechnology and Medicine, Dubrovnik, Croatia (7-13 July 2013)
Brîndușa Alina Petre, Laura Ion, Claudia Andrieș Brian Gau, Michael Gross, “Molecular characterization of neuronal protein aggregates by Mass spectrometry-based footprinting methods” – Oral presentation
Laura Ion, Claudia Andrieș, Claudia Cozma, Michael Przybylski and Brîndușa-Alina Petre, “Lysosomal Storage Diseases: MRM-MS and fluorimetric diagnostics” – Oral presentation
MSLife – High Performance Mass Spectrometry: Integrating new Tools & Methods with Applications in Life Sciences, Konstanz, DE (26-28 August 2013)
Brîndușa Alina Petre, Claudia Andrieș, Mihaela Stumbaum, Bogdan Bernevic, Martina Ulrich, Gerd Doering, Tingting Tu, Michael Gross, “Protein Nitration Analysis using Affinity- Mass Spectrometry” – Oral presentation
18th Romanian International Conference on Chemistry and Chemical Engineering, Sinaia, RO (4-7 September 2013)
Brînduşa Alina Petre, Laura Ion, Claudia Andries, Brian Gau, Gabi Drochioiu, Michael Gross, “Hydrogen/deuterium exchange – mass spectrometry for molecular characterization of neuronal protein aggregates” – Oral presentation
Laura Ion, Claudia Cozma, Michael Przybylski, Gabi Drochioiu and Brîndușa-Alina Petre, “Lysosomal Storage Disease: Characterization and Diagnostics” – Oral presentation
Claudia Andries, Mihaela Stumbaum, Gabi Drochioiu, Michael Przybylski si Brînduşa-Alina Petre, “Mass spectrometric based method for rigorous characterization of antibody-antigen interaction” – Oral presentation