O1<\/strong>. To design and synthetise new polifunctional nitrogen podants (e.g. type P1 <\/strong>to P4<\/strong>) having in the same molecule at least a p\u2013reach and a p\u2013deficient heterocycle connected via different spacers. Tasks to be accomplished: logic gates (type spaced), chemosensor, anticancer (DNA intercalators) and\/or antimicrobial. Example: podant P1<\/strong> could act as a spaced NOR logic gate (fluorophore-spacer-receptor), can complex either H^{+<\/sup> or Mm+<\/sup>(two inputs) and is expected to quench fluorescence output via PET process from the imidazole fluorophore (one output); in the same time\u00a0 P1<\/strong> could act as a DNA intercalator; obviously, a third function will be complexation with metals (chemosensor);<\/p>\n}

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O2<\/strong>. To design and synthetise new nitrogen polifunctional podants (e.g. type P5, P6<\/strong>) having in molecule only a p\u2013reach nitrogen heterocycle connected via different spacers with the receptor.<\/p>\n

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Tasks to be accomplished: logic gates (P5<\/strong>: fluorophore-spacer-receptor; P6<\/strong>: fluorophore-spacer-fluorophore-spacer-receptor), chemosensor for metals, antimicrobial;<\/p>\n

O3<\/strong>. To design and synthetise new polifunctional nitrogen macrocycles (e.g. type P7<\/strong>) having in the same molecule at least two p\u2013reach and two p\u2013deficient heterocycle connected\u00a0 via different spacers. Tasks to be accomplished: logic gates (fluorophore-spacer-receptor-fluorophore), chemosensor, maybe anticancer (DNA intercalators);<\/p>\n

O4<\/strong>.\u00a0To design and synthetise new polifunctional nitrogen podant structures (e.g. type P8<\/strong>) having in molecule only a p\u2013deficient nitrogen heterocycle connected via different spacers with a bis-alkylator unit. Tasks to be accomplished: chemosensor, anticancer DNA alkylator, antimicrobial.<\/p>\n

O5<\/strong>.\u00a0To elaborate new experimental setup procedure for nitrogen derivatives, and\/or to adapt the existing one, particularly environmentally friendly methods, using MW and\/or US technology.<\/p>\n

O6<\/strong>. Increasing the research skills and abilities of the young Ph-D and master students.<\/p>\n

O7<\/strong>. To establish new collaboration relationship with partners from inside and outside of Romania that is working in the related fields.<\/p>\n","protected":false},"excerpt":{"rendered":"

O1. To design and synthetise new polifunctional nitrogen podants (e.g. type P1 to P4) having in the same molecule at least a p\u2013reach and a p\u2013deficient heterocycle connected via different spacers. Tasks to be accomplished: logic gates (type spaced), chemosensor, anticancer (DNA intercalators) and\/or antimicrobial. Example: podant P1 could act as a spaced NOR logic […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/pages\/3"}],"collection":[{"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/comments?post=3"}],"version-history":[{"count":9,"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/pages\/3\/revisions"}],"predecessor-version":[{"id":198,"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/pages\/3\/revisions\/198"}],"wp:attachment":[{"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/media?parent=3"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}