2011 (3 months). Stage I.\u00a0 Synthesis and structural analysis of the necessary intermediary<\/strong><\/p>\n

Synthesis will be performed according to the following scheme:<\/p>\n

<\/a><\/p>\n

A.I.1.<\/strong> Synthesis of 6-member ring nitrogen \u03c0\u2013deficient and 5-member ring nitrogen \u03c0\u2013reach heterocycles by conventional methods<\/p>\n

A.I.2.<\/strong> Synthesis of diols with acetophenone skeleton by conventional methods<\/p>\n

A.I.3.<\/strong> Elemental and structural analysis of the obtained structures. Final stage report. The structure of the newly compounds will be proven through elemental and structural analysis: IR, NMR.<\/p>\n

A final stage report will be accomplished and it will be present on the web page of the project.<\/p>\n

2012. Stage II.\u00a0 Synthesis and structural analysis of intermediars and podant derivatives<\/strong><\/p>\n

In this stage there will be bring it contributions to objectives O1, O2, O5-O7.<\/strong><\/p>\n

A.II.1.<\/strong> Synthesis of 5- and 6- member ring nitrogen heterocycles and diols intermediary (obtained in stage I by conventional methods), using MW and\/or US technology.<\/p>\n

A.II.2.<\/strong> Synthesis of new polifunctional nitrogen podant type P1 <\/strong>having in the same molecule a \u03c0\u2013reach and a \u03c0\u2013deficient heterocycle connected via different spacers. In the second step, P1 <\/strong>will be tested as chemosensor (complexation with metals, M^{m+<\/sup>) and as logic gate of type NOR (complex either H+<\/sup> or Mm+<\/sup>), P1 <\/strong>being a fluorophore-spacer-receptor system.<\/p>\n}

<\/a><\/p>\n

A.II.3.<\/strong> Synthesis of new polifunctional nitrogen podant type P2 <\/strong>having in the same molecule a \u03c0\u2013reach\u00a0 and a \u03c0\u2013deficient heterocycle connected\u00a0 via different spacers. In the second step, P2 <\/strong>will be tested as chemosensor (complexation with metals, M^{m+<\/sup>) and as logic gate with three inputs (2H+<\/sup> and Mm+<\/sup>) and one output (fluorescence), a fluorophore-spacer-receptor-spacer-fluorophore system.<\/p>\n}

<\/a><\/p>\n

A.II.4.<\/strong> Synthesis of new polifunctional nitrogen podant type P5<\/strong> having in molecule only a \u03c0\u2013reach<\/p>\n

<\/a><\/p>\n

nitrogen heterocycle connected via different spacers with the receptor. In the second step, P5 <\/strong>will\u00a0be tested as chemosensor (complexation with metals, M^{m+<\/sup>) and as logic gate (two input: H+<\/sup> and Mm+<\/sup>and one output: fluorescence), a fluorophore-spacer-receptor system.<\/p>\n}

A.II.5. <\/strong>Biologically active evaluation. The newly obtained compounds will be tested as follow:\u00a0 P1<\/strong> and P2 <\/strong>as DNA intercalators, P5<\/strong> as antimicrobial.<\/p>\n

A.II.6.<\/strong> Elemental and structural analysis of the obtained structures. Final stage report. The structure of the newly compounds will be proven through elemental and structural analysis: IR, NMR, UV-Vis and fluorescence, MS, X-ray. A final stage report will be accomplished and it will be present on the web page of the project. Manuscript preparation for publication.<\/p>\n

2013. Stage III.\u00a0 Synthesis and structural analysis of intermediars and podant derivatives<\/strong><\/p>\n

In this stage there will be bring it contributions to objectives O1, O2, O5-O7.<\/strong><\/p>\n

A.III.1.<\/strong> Synthesis of the necessary intermediary (as we described in stage I)<\/p>\n

A.III.2.<\/strong> Synthesis of new polifunctional nitrogen podant type P3 <\/strong>having in the same molecule a \u03c0\u2013reach\u00a0 and a \u03c0\u2013deficient heterocycle. In the second step, P3 <\/strong>will be tested as chemosensor (complexation with metals, M^{m+<\/sup>) and as logic gate with three inputs (2H+<\/sup> and Mm+<\/sup>) and one output (fluorescence), a fluorophore-spacer-receptor-spacer-fluorophore system.<\/p>\n}

<\/a><\/p>\n

A.III.3.<\/strong> Synthesis of new polifunctional nitrogen podant type P6<\/strong> having in molecule only a \u03c0\u2013reach nitrogen heterocycle. In the second step, P6 <\/strong>will be tested as chemosensor (complexation with metals, M^{m+<\/sup>) and as logic gate (two input: H+<\/sup> and Mm+<\/sup>and one output: fluorescence), a fluorophore-spacer-fluorophore-spacer-receptor system.<\/p>\n}

<\/a><\/p>\n

A.III.4.<\/strong> Synthesis of new polifunctional nitrogen podant type P4<\/strong> having in the same molecule a \u03c0\u2013reach and a \u03c0\u2013deficient heterocycle connected via different spacers. In the second step, P4 <\/strong>will be tested as chemosensor (complexation with metals, M^{m+<\/sup>) and as logic gate with three inputs (2H+<\/sup> and Mm+<\/sup>) and one output (fluorescence), a fluorophore-spacer-receptor-spacer-fluorophore system.<\/p>\n}

<\/a><\/p>\n

A.III.5. <\/strong>Biologically active evaluation. The newly obtained compounds will be tested as follow:\u00a0 P3 <\/strong>as DNA intercalators and P4 <\/strong>and P6<\/strong> as DNA intercalators and antimicrobials.<\/p>\n

A.III.6.<\/strong> Elemental and structural analysis of the obtained structures. Final stage report. The structure of the newly compounds will be proven through elemental and structural analysis: IR, NMR, UV-Vis and fluorescence, MS, X-ray. A final stage report will be accomplished and it will be present on the web page of the project. Manuscript preparation for publication.<\/p>\n

2014. Stage IV.\u00a0 Synthesis and structural analysis of macrocycles and podant derivatives<\/strong><\/p>\n

In this stage there will be bring it contributions to objectives O3-O7.<\/strong><\/p>\n

A.IV.1.<\/strong> Synthesis of the necessary intermediary (as we described in stage I)<\/p>\n

A.IV.2.<\/strong> Synthesis of new polifunctional nitrogen podant type P8<\/strong> having in molecule a \u03c0\u2013deficient heterocycle connected via different spacers with a bis-alkylator unit.<\/p>\n

<\/a><\/p>\n

In the second step, P8 <\/strong>will be tested as chemosensor (complexation with metals, M^{m+<\/sup>).<\/p>\n}

A.IV.3.<\/strong> Synthesis of new nitrogen macrocycle type P7<\/strong> having in the same molecule at a \u03c0\u2013reach and a \u03c0\u2013deficient heterocycle connected via different spacers. In the second step, P7 <\/strong>will be tested\u00a0as chemosensor (complexation with metals, M^{m+<\/sup>) and as logic gate with three inputs (2H+<\/sup> and Mm+<\/sup>) and one output (fluorescence), a fluorophore-spacer -receptor-spacer-fluorophore system.<\/p>\n}

<\/a><\/p>\n

A.IV.5.<\/strong> Biologically active evaluation. The newly obtained compounds will be tested as follow:\u00a0 P7 <\/strong>as DNA intercalator and P8 <\/strong>as DNA alkylator and antimicrobial.<\/p>\n

A.IV.6.<\/strong> Elemental and structural analysis of the obtained structures. Final stage and grant report. The structure of the newly compounds will be proven through elemental and structural analysis: IR, NMR, UV-Vis and fluorescence, MS, X-ray. A final stage report will be accomplished and it will be present on the web page of the project. Manuscript preparation for publication.<\/p>\n","protected":false},"excerpt":{"rendered":"

2011 (3 months). Stage I.\u00a0 Synthesis and structural analysis of the necessary intermediary Synthesis will be performed according to the following scheme: A.I.1. Synthesis of 6-member ring nitrogen \u03c0\u2013deficient and 5-member ring nitrogen \u03c0\u2013reach heterocycles by conventional methods A.I.2. Synthesis of diols with acetophenone skeleton by conventional methods A.I.3. Elemental and structural analysis of the […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/pages\/4"}],"collection":[{"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/comments?post=4"}],"version-history":[{"count":8,"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/pages\/4\/revisions"}],"predecessor-version":[{"id":199,"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/pages\/4\/revisions\/199"}],"wp:attachment":[{"href":"http:\/\/teclu.chem.uaic.ro\/chemosensors\/wp-json\/wp\/v2\/media?parent=4"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}