{"id":27,"date":"2014-12-04T14:00:17","date_gmt":"2014-12-04T12:00:17","guid":{"rendered":"http:\/\/teclu.chem.uaic.ro\/elenabicu\/?page_id=27"},"modified":"2014-12-04T14:36:53","modified_gmt":"2014-12-04T12:36:53","slug":"objectives","status":"publish","type":"page","link":"http:\/\/teclu.chem.uaic.ro\/elenabicu\/objectives\/","title":{"rendered":"Objectives"},"content":{"rendered":"

The aims of our project are to:<\/p>\n

develop new compounds with anticancer potential;<\/li>\n
fit the nature of the substituents onto the starting materials in certain cases in order to reinforce the metabolic stability of final compounds;<\/li>\n
measure the inhibitory activity of new compounds on human farnesyltransferase;<\/li>\n
measure the inhibitory activity of new compounds on tubulin polymerization;<\/li>\n
develop original syntheses for target compounds;<\/li>\n
evaluate the anticancer potential of synthesized compounds;<\/li>\n
establish structure-activity relationships for resulting anticancer agents;<\/li>\n
create a real opportunity for the project leader to obtain a stable professional position in a research unit in Romania;<\/li>\n
continue working with research teams from abroad, especially in the field of medicinal chemistry, in order to produce visible results at international level.<\/li>\n<\/ul>\n
Estimated results:<\/p>\n
- Obtaining new potential anticancer molecules in vitro with a\u00a0known mode of action, the aim being to select the best candidates for further evaluation in vivo.<\/li>\n
- Publication of at least four\u00a0articles in international journals with impact factor> 2, which will give to the project manager and his team increased international visibility in the field.<\/li>\n
- The research findings will be presented annually to an international congress.<\/li>\n<\/ul>\n
  <\/div>\n
  <\/div>\n","protected":false},"excerpt":{"rendered":"
  The aims of our project are to: develop new compounds with anticancer potential; fit the nature of the substituents onto the starting materials in certain cases in order to reinforce the metabolic stability of final compounds; measure the inhibitory activity of new compounds on human farnesyltransferase; measure the inhibitory activity of new compounds on tubulin […]<\/p>\n","protected":false},"author":55,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/teclu.chem.uaic.ro\/elenabicu\/wp-json\/wp\/v2\/pages\/27"}],"collection":[{"href":"http:\/\/teclu.chem.uaic.ro\/elenabicu\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/teclu.chem.uaic.ro\/elenabicu\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/teclu.chem.uaic.ro\/elenabicu\/wp-json\/wp\/v2\/users\/55"}],"replies":[{"embeddable":true,"href":"http:\/\/teclu.chem.uaic.ro\/elenabicu\/wp-json\/wp\/v2\/comments?post=27"}],"version-history":[{"count":3,"href":"http:\/\/teclu.chem.uaic.ro\/elenabicu\/wp-json\/wp\/v2\/pages\/27\/revisions"}],"predecessor-version":[{"id":44,"href":"http:\/\/teclu.chem.uaic.ro\/elenabicu\/wp-json\/wp\/v2\/pages\/27\/revisions\/44"}],"wp:attachment":[{"href":"http:\/\/teclu.chem.uaic.ro\/elenabicu\/wp-json\/wp\/v2\/media?parent=27"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}