The main goal of the proposed project<\/b><\/em><\/span> is to develop innovative semisolid formulations for skin-directed therapy of CTCL, in which the bioactive principle is confined within a biocompatible inorganic matrix, in order to attain maximum efficiency with minimum side effects when administered topically.<\/h5>\n

The objectives<\/b> <\/em>of the project are:<\/h5>\n

1. Development of modified drug delivery systems (MDDS) by immobilization of CTCL-specific anticancer drugs into biocompatible nanoporous matrices within 10 months from the start of the project.<\/h5>\n

2. Assessment of the role that the matrix nanostructure plays on the release behavior of selected model drugs: in-vitro <\/i>release kinetics<\/h5>\n

3. Development of semisolid pharmaceutical product incorporating the MDDS suited for skin-directed therapy of CTCL<\/h5>\n

4. Evaluation of in-vitro<\/i> dissolution of CTCL-specific active principles from the formulated semisolid pharmaceutical product<\/h5>\n

5. \u00a0In- vivo<\/i> evaluation of chemoprevention potential and therapeutic efficacy of MDDS-based topical formulations<\/h5>\n

6.\u00a0 Transfer of the research results into private sector: patent application and scale-up.<\/h5>\n","protected":false},"excerpt":{"rendered":"

The main goal of the proposed project is to develop innovative semisolid formulations for skin-directed therapy of CTCL, in which the bioactive principle is confined within a biocompatible inorganic matrix, in order to attain maximum efficiency with minimum side effects … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":50,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/teclu.chem.uaic.ro\/top-ctcl\/wp-json\/wp\/v2\/pages\/21"}],"collection":[{"href":"http:\/\/teclu.chem.uaic.ro\/top-ctcl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/teclu.chem.uaic.ro\/top-ctcl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/teclu.chem.uaic.ro\/top-ctcl\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"http:\/\/teclu.chem.uaic.ro\/top-ctcl\/wp-json\/wp\/v2\/comments?post=21"}],"version-history":[{"count":7,"href":"http:\/\/teclu.chem.uaic.ro\/top-ctcl\/wp-json\/wp\/v2\/pages\/21\/revisions"}],"predecessor-version":[{"id":22,"href":"http:\/\/teclu.chem.uaic.ro\/top-ctcl\/wp-json\/wp\/v2\/pages\/21\/revisions\/22"}],"wp:attachment":[{"href":"http:\/\/teclu.chem.uaic.ro\/top-ctcl\/wp-json\/wp\/v2\/media?parent=21"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}