Prof. dr. Ionel Mangalagiu

Curriculum Vitae

CURRICULUM VITAE

Name: MANGALAGIU IONEL

Citisenship: Romanian
Birth Date: July, 06, 1964, CIORTESTI village, district of IASI, Romania.
Position and degree hold: Professor, Ph-D
Address(mailing): Professor Ionel MANGALAGIU, “Al. I. Cuza” University of Iasi, Faculty of Chemistry, B-dul Carol, No.11, 700506 IASI, ROMANIA
Fax + (40)+ 232 201313, Phone + (40)+ 232 201343.
Electronic mail:
Web site: http://teclu.chem.uaic.ro/mangalagiu
Brainmap ID: U-1700-039Y-5778
ORCID ID: 0000-0002-4632-5076
Researcher ID(Web of Science): H-2421-2017
Researcher ID (Web of Scopus): 55761251200

Education:

1970-1978, Primary and the secondary school in my village
1978-1982, Medical High School, Iasi,
1983-1984, Military service
1985-1990, Chemical Technological Faculty, Chemistry- Physics Section, Polytechnic Institute of Iasi, Romania.

Achievements:

1982, Medical instructor diploma;
1990, Bachelor in Chemistry and Physics;
1990: Assisting professor, Organic Chemistry Department, Alexandru Ioan Cuza University of Iasi, Romania;
1995: Lecturer, the same department;
1996: Doctor’s Degree in Chemistry. The title of my theses was “New Ylide Compounds In the 1,2-Diazine Series”, lead by Prof.dr.doc. MAGDA PETROVANU;
1997: Associate professor, the same department;
2001: Professor, the same department;
2002: Ph-D Supervisor.
2006-2012, 2016-2020: Member of the National Council for Titles, Diplomas and Certificates of Romania- Chemistry;
since 2012: President of the Appeal National Council for Titles, Diplomas and Certificates of Romania- Chemistry;
2005-2008: Executive Director of Doctoral School, Faculty of Chemistry;
2007-2011, 2017-2020: Member of the National Research Council of Romaninan;
2000-2004: Vice dean of faculty;
2005-2008: Head of Organic and Biochemistry Department;
2012-2016: Dean of Chemistry Faculty;
2016-present: Vice-Rector of Alexandru Ioan Cuza University of Iasi, Romania;
since 2002: Erasmus – Socrates coordinator for international cooperation with Technical University of Braunschweig (Technische Universität Braunschweig), Konstanz (University of Konstanz, Institut fur Chemie, Germany), Anger (Universite D’Angers, France) and Cagliari (Università degli Studi di Cagliari, Italy);

Invited speaker to foreign universities:

“Microwave Assisted Reactions in Organic Synthesis“, Technische Universität Braunschweig, Germany, August 27, 2005;
“Coronands“, Technische Universität Braunschweig, Germany, July 18, 2007.
“Coronands and Azaheterocycles: New Aproches“, Technische Universität Braunschweig, Germany, June 27, 2008.
“Nanomaterials with Azaheterocycles Skeleton“, Universite D’Angers, France, July 10, 2008.
“Nitrogen Heterocycles: Old Stories, new Approaches and Perspectives”, University of Konstanz, Konstanz, October 16-th 2014.
“Five and Six Member Ring Azaheterocycles as Intelligent Building Blocks for Multiple Tasks”, University of Florence, Italy, June 20-th 2016.
“Azaheterocycles: chemistry and applications“, Institutul de Chimie al Academiei de Stiinte al Moldovei, Chisinau, October 16-th 2016.
“New Achievements in the Five and Six Member Ring Azaheterocycles: Chemistry and Applications”, Technische Universität Braunschweig, Germany, August 31-st 2017.
“New achievements in medicinal chemistry of five and six member ring nitrogen heterocycles”, Universite Paris Sud, Paris, France, July 12-th 2018.
“Azaheterocycles”, University of Viena, Viena, Austria, December 2-nd, 2022.

Honours, Awards, Fellowships, Membership of Professional Societies (selections)

September 1994 – August 1995. Scholarship in Norway, University of Oslo, (competition: The Council of Europe for the East European countries (China including). Specialization in the field of “Application of Organometallic Chemistry to Synthetic Problems”, under the supervising of dr. Kjell Undheim.
August – September, 1998. NATO Fellowship. Postdoctoral study: NATO Advanced Study Institute in Management of Research&Developement&Inovation in Chemistry, Budapest, Hungary;
June – September, 2003. DAAD – NATO Fellowship. Visiting Professor: Ludwig Maximilianus University Munchen, Institut fur Organische Chemie; field: ‘Preparation of Polyfunctional Aryl, Alkenyl and Heteroaryl Magnesium Reagents and their Applications in Organic Synthesis’; Paul Knochel team ;
July- August, 2005. Visiting Professor, University of Konstanz, Germany; field: ‘Solid-Phase Peptide Synthesis’; Michael Przybylski team;
July- August, 2006. Visiting Professor, University of Konstanz, Germany; field: ‘Solid-Phase Peptide Synthesis’; Michael Przybylski team;
October 26-th, 2006. Alexandru Ioan Cuza University of Iasi Award for Excellency in Research, Alexandru Ioan Cuza University University Days, Iasi, Romania;
July- August, 2007. Erasmus/Socrates mission to: TU Braunschweig (Germania, July 13-19) and University of Konstanz, Institut fur Chemie (Germania, July 20 – August 5);
July- August, 2007. Visiting Professor: Technische Universität Braunschweig, University of Konstanz, Institut fur Chemie, Germany; field: ‘Supramolecular Chemistry’ respectively “Highly Fluorescent Materials through Microwave Chemistry”; Mathias Tham and Prof. Ulrich Groth respectively;
June- July, 2008. Erasmus/Socrates mission to: Universite D’Angers (France, July 13-25) and University of Konstanz, Institut fur Chemie (Germany, June 30 – July 12);
July- August, 2008. Visiting Professor: Technische Universität Braunschweig, University of Konstanz, Institut fur Chemie, Germany; field: ‘Supramolecular Chemistry’ respectively “Highly Fluorescent Materials through Nonconventional methods”; Wolf DuMont and Prof. Ulrich Groth respectively;
June 04-06, 2009. Excellency Diploma and Gold Medal. Patent awarded: “Steroidal Glycosides: Biological Active Compounds of Vegetal Origin”. Inventica 2009, Iasi, Romania;
May 12-14, 2011. Excellency Diploma in Research, Technical University of Moldova for “Research in the field of Azaheterocycles”. Euroinvent 2011, Iasi, Romania;
June 8-10, 2011. Gold Medal. Group of patents awarded. Inventica 2011, Iasi, Romania;
December 19, 2011. Costin D. Nenitescu Medal, for outstanding achievements in chemistry. Roumanian Society of Chemistry;
November 8-10, 2012. Gold Medal. Patent awarded: Procedure for obtaining of oil nanodispersion with regenerative capacity. 37-th International Invention Show, Sibenik, Croatia;
December 4-6, 2015. Silver Medal. Patent awarded: “11,12-Bis-p-tolyl-piridazonil-drim-5(6),8(9)-diene-7-one with antifungal and antibacterial properties”, Kaohsiung International Invention and design Expo 2015, Kaohsiung, Taiwan;
November 25-28, 2015. Silver Medal. Patent awarded: “Stimulation procedure of grapes crop” Infoinvent 2015, Chisinau, Moldova;
Member of International Society of Heterocyclic Chemistry;
Member of the Romanian Chemical Society;
Member of the Romanian Society of Biomaterials;
Member of the American Chemical Society (ACS ID- 2405478);

Other Achievements:

Reviewer (referee) for:

FP7 program (since 2008) and Horizont 2020 (since 2015) Cod: EX2002B025670;
INTAS program of grants (EU), since 2002;
CNCSIS, CEEX, PNCDI program of grants of Romanian Ministry of Research, since 2001.

Member in Editorial Board / Guest Editor of the following journals:

Current Medicinal Chemistry, Bentham Sicence, UK;
Molecules (Organic Chemistry Section), MDPI, Switzerland;
Mini-Reviews in Organic Chemistry, Bentham Sicence, UK;
Current Microwave Chemistry, Bentham Sicence, UK;
Acta Chimica Iasi (former Analele Stiintifice ale Universitatii “Al.I Cuza” Iasi), Ed. Univ. Alexandru Ioan Cuza Iasi, Iasi, Romania;
The Bulletin of the Polytechnic Institute from Iasi, Chemistry and Chemical Engineering Section, Ed. Univ. Tehn. Ghe. Asachi Iasi, Iasi, Romania;
New Frontiers in Chemistry, Ed. Univ. de Vest Timisoara, Timisoara, Romania;
Journal of the European Society of Mathematical Chemistry, European Society of Mathematical Chemistry, http://chem.ubbcluj.ro/jesmc/;
Studia Universitatis Moldaviae, Ed. Universitatii de Stat din Moldova, ISSN 1814-3237 ISSN online 1857-498X http://studiamsu.eu/stiinte-ale-naturii/
Guest Editor: Special Issue ” Microwave Assisted Reactions: A Modern Useful Tool in Medicinal Chemistry” (2019), Molecules, MDPI;
Guest Editor: Special Issue “Huisgen 3+n Dipolar Cycloaddition Reactions: An Accessible and Useful Tool in Modern Organic and Heterocycle Synthesis” (2020), Molecules, MDPI;
Guest Editor: Special Issue “Research Progress and Application of Natural Compounds” (2022), Molecules, MDPI;

Reviewer to the following journals:

European Journal of Medicinal Chemistry, Elsevier, Netherlands;
Ultrasonics Sonochem, Elsevier, Netherlands;
Comptes Rendus Chimie, Elsevier, Netherlands;
Bioorganic & Medicinal Chemistry, Elsevier, Netherlands;
Bioorganic & Medicinal Chemistry Letters, Elsevier, Netherlands;
Tuberculosis, Elsevier, Netherlands;
Arabian Jornal of Chemsitry, Elsevier, Netherlands;
Inorganica Chimica Acta, Elsevier, Netherlands;
Future Medicinal Chemistry, Future Sci, UK
ChemMedChem, RSC, UK;
Monatshefte für Chemie, Springer, Germany;
Medicinal Chemistry Research, Springer, Germany;
Research on Chemical Intermediates, Springer, Germany;
Central European Journal of Chemistry, Springer, Germany;
Journal of Heterocyclic Chemistry, Wiley, New York, USA;
Journal of Physical Chemistry, ACS, USA;
Heteroatom, Wiley, New York, USA;
Plos One, USA;
Arkivok, Arkat Gainesville, FL, USA;
Polycyclic Aromatic Compounds, Taylor&Francis, US
Current Organic Chemistry, Bentham Sicence, UK;
Current Medicinal Chemistry, Bentham Sicence, UK;
Current Microwave Chemistry, Bentham Sicence, UK;
Letters in Drug Design and Discovery, Bentham Science, UK;
Journal of Chemistry, Hindawi Publishing Corporation, Egipt/USA
Molecules, MDPI, Switzerland;
Metabolites, MDPI, Switzerland;
Amino Acids, MDPI, Switzerland;
Molbank, MDPI, Switzerland;
International Journal of Molecular Sciences, MDPI, Switzerland;
Revue Roumaine de Chimie, Ed. Academiei, Bucuresti, Romania;
Roum. Biotech. Lett., Ed. Universitatii Bucuresti, Romania;
Analele Stiintifice ale Universitatii Alexandru Ioan Cuza Iasi, Ed. Univ. Iasi, Iasi, Romania.
New Frontiers in Chemistry, Ed. Univ. de Vest Timisoara, Timisoara, Romania;
Studia UBB Cluj, Cluj, Romania.;

Language skills: English- very good; French- good

Didactic and Scientific Background

Didactic Carer:

Beginning with the academic year 1995- 1996 I’m teaching the following courses:

Relation between Structure anb Biological Activity of the Organic Compounds (at the 3^rdyear Biochemistry Section and Master students).
Natural Products (at the 4^th year of Chemistry Section and year Biochemistry Section).
Organic Chemistry I (at the 2^nd year of Chemistry Section).
Amphionic Compouds (Master)
Microwave and Ultrasounds Assisted Reactions (Doctoral School).
Drug Design (Master).

Research:

Main field of research is focused on Chemistry of Heterocyclic Compounds, with three area of expertise:

Chemistry and Health: Nitrogen Heterocycles Chemistry and Medicinal Chemistry;
Chemistry and Nanoscience: Nitrogen and/or Oxygen Macrocycles, Supramolecular Chemistry;
Chemistry and Sustainable Development: Eco-friendly Reactions using Microwave and Ultrasounds Assisted Reactions.

Inside of these areas the following main aspects are followed:

Chemistry and Health: the development of new useful reactions for the synthesis of heterocyclic compounds, and in particular, reactions involving reactive species such as cycloimmoniu ylides. The main outcomes of these directions are: new nanobiomaterials with and without nitrogen heterocycle moieties, new nitrogen heterocycles biologically active [potentials drugs (anticancer, anti-HIV, antituberculosis, antimicrobials) and grow up factors for agriculture], modified oligo- and poli- peptides (including anti- Alzheimer), etc.;
Chemistry and Nanoscience: in this field our efforts are orientated in the arrea of oxa- and oxaaza- coronands, nano-electronics and nano-devices, nanobiomaterials (for dentistry including), new highly fluorescent materials, chemical captors (chemosensors);
Chemistry and Sustainable Development: microwave and ultrasounds assisted reactions; these technologies allow us to develop environmental friendly methods, with lower waste and environmental friendly impact [“green” chemistry];

Keywords: heterocycles, diazine, ylides, oxa- oxaaza- coronands, microwave, ultrasounds, cycloadditions, fluorescent materials, nanobiomaterials, antituberculosis, antimicrobials, anticancer, anti-HIV, nano-electronics and nano-devices (logic gates, chemosensors), organic and medicinal chemistry, microwave, ultrasounds, nano-electronics and nano-devices; “green” chemistry.

Significant Results:

Present research team: 4 postdocs, 5 pH-D students, 8 master and graduating students;

16 Ph-D students finished their thesis under my supervision:

Moldoveanu C. (December 2007);
Zbancioc Ghe. (December 2007);
Butnariu (cas. Tucaliuc) R. (June 2008);
Balan (cas. Zbancioc) A.M. (May 2009);
Florea (cas. Boita) O. (October 2009);
Risca M. (December 2009);
Bejan (cas. Antoci) V. (February 2010);
Mantu D. (November 2010);
Astefanei D. (December 2013);
Maftei D. (September 2014);
Al-Matarneh C. (October 2016);
Olaru A. (July 2018);
Tiru L. (September 2018);
Sardaru M. (November 2020);
Diaconu D. (February 2021);
Bucur St. (September 2021).

Foreign doctoral researchers in my labs:

Florian Roβner (Goethe University Frankfurt), Germany (2021)
Renata Eftenyeva (Yuriy Fedkovych National University Cernauti, Chemical Dep.,) Ukraina (2015-2016)
Nejjar El Ansari Zineb (Université Abdelmalek Essaadi, Faculté des Sciences de Tétouan) Maroco (2014)

Former postdocs:

Antoci Vasilichia, Romania (2012-2013)
Edu Carolina, Moldova (2013)
Chibac Andreea, Romania (2014-2015)
Mantu Dorina, Romania (2014-2015)
Murariu Manuela, Romania (2014-2015)
Zbancioc Ana Maria, Romania (2014-2015)

Total scientifically papers: over 200, from which:

papers in ISI quoted publications (Web of Science-Core Collection) over 150, almost half of them in journals from first quartile Q1 (top 25%) and second quartile Q2 (top 26-50%) (Bioorg. Med. Chem., Curr. Med. Chem., Eur. J. Med. Chem., Eur. J. Org. Chem., Future Med. Chem, J. Heterocyclic Chem., J. Phys. Chem., Macromolecules, Molecules, Synthesis, Synlett, Tetrahedron, Tetlett., Ultrason. Sonochem., etc.);
papers presented to meetings: over 150 (over 100 international);

Citations, from which:

Web of Science-Core Collection: Hirsh: 28 (Number of citations: over 2000)
Scopus: Hirsh: 27 (Number of citations: over 2400)
Google: Hirsh: 32 (Number of citations: over 3000)

Invited Speaker to foreign universities: 8;

Invited Plenary lectures (representative)- over 20;

Patents: 14;

International grants grants as director. Total number – 4

1 HORIZONT 2020 grant as director (2021-2023);
1 FP7 grant as director (2010-2013, value 194.000 Euro);
1 NATO grant as director (2006-2007, value 5000 Euro);
1 bilateral grant as director with Moldova (2010-2013, value 10.000 Euro);
Management Committee member (Romanian representative) in the COST Actions CM1307 (2014-2018) and MP0901 (2009-2013);

National grants as director. Total number – 17

1 PN-III-PCE Exploratory Research grant as director (2021-2023, with Romanian Ministry of Research Education);
two PN-II Ideas grant as director (Value: 450.000,00 Euro each) (with Romanian Ministry of Research Education);
two CEEX grants as director (Value: 900.000,00 Euro both) (with Romanian Ministry of Research Education);
1 CEEX grant as partner director (Value: 100.000,00 Euro) (with Romanian Ministry of Research Education) ;
1 grant with World Bank as director (Value: 90.000,00 $ SUA);
8 grants type A (with Romanian Ministry of Research Education) as director: 1998 (value 3.000 Euro), 2003 (value 2.000 Euro), 2004 (value 3.000 Euro), 2005 (value 5.000 Euro) ; 2006 (value 10.000 Euro), 2007 (value 10.000 Euro), 2008 (value 10.000 Euro).

January 2023