FACULTY OF PHARMACY
PHARMACEUTICAL TECHNOLOGY DEPARTMENT
Team:
Lecturer PhD Lacramioara Ochiuz – is the team leader of Partner1 . She is 38 years old, MD, PhD, lecturer in Pharmaceutical Technology Department, Faculty of Pharmacy, ”Grigore T. Popa” University of Medicine and Pharmacy, Iasi. She graduated Faculty of Pharmacy in 1998, has an experience of 3 years in clinical pharmacology and healthy insurance in Israel and in 2010 defended her PhD thesis in the field of formulation and bioavailability increase of alendronate. She was involved in three national grants as specialist in pharmaceutical formulation and in vitro release control. She performed several training internships abroad, among which we quote : The Spray Drying Technique – a performant method to obtain microparticles for modified release of drug substances, Faculty of Pharmacy, Dep. of Pharmaceutical Technology, Valencia, Spain, 2007; Microemulsions – modern pharmaceutical dosage forms intended for topical aplication, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ljubljana, Slovenia, 2011. She has published over 20 articles of which 6 in ISI indexed journals and 10 monographs in the field of pharmaceutical formulation of which 3 in the topic of encapsulation and modified drug delivery, biopharmacy and bioavailability and pharmaceutical development and scale-up processes in pharmaceutical industry.
Few of the most important publications of Dr. Farm. Lacramioara Ochiuz are:
1. A.M. Tomoiagă, L. Ochiuz, A. Vasile, Sonochemical development of nanoparticulate magnetic therapeutic systems as 5-fluorouracil carriers, Journal of Nanoechnology in Diagnosis and Treatment, 1, 2013, 26 – 35.
2. L. Ochiuz, G. Popa, G. Lisa, A.M. Tomoiagă*, M. Popa, Microencapsulation of metoprolol tartrate into chitosan for improved oral administration patients compliance, Industrial & Engineering Chemistry, 52, 2013, 17432 – 17441.
3. L. Ochiuz, Polymeric Nanomedicines in the Therapy of Inflammatory Diseases, in Polymeric Nanomedicine, M. Popa, C.V. Uglea eds. Bentham Sciences Publishers, 2013, ISBN 978 – 1- 60805-628-6
4. L. Ochiuz, A. Stanescu, I. Stoleriu, V. Dorneanu, I. Popovici, D. Lupuleasa: „Investigations on the in vitro release mechanism of propiconazole nitrate from hydrophilic gel formulations”, Farmacia, 59(6), 2011, 842 – 852;
5. L.Ochiuz, P.J.Esteban: Preparation and Characterisation of Alendronate-Loaded Chitosan Microparticles Obtained through the Spray Drying Technique”, Medicinal Chemistry, vol. 5, no. 2, 2009, 191 – 196
Prof. univ. dr. Cătălina Elena Lupușoru– 60 years, MD, PhD, Professor – Pharmacology, First Department, Faculty of Medicine, “Gr. T. Popa” University of Medicine and Pharmacy, Iaşi.
Dr. Cătălina Elena Lupuşoru received her MD in 1979 and her PhD in 1996, from “Gr. T. Popa” University of Medicine and Pharmacy, Iaşi, Romania. During 1986-1990, Dr. Cătălina Elena Lupuşoru was scientific researcher in Cantacuzino Institute, Iaşi. She was lecturer (1990-1999), then associated professor (1999-2002) and after that professor at the Department of Pharmacology-Algesiology, University of Medicine and Pharmacy “Gr. T. Popa”, Iasi, Romania (since 2002). Dr. Cătălina Elena Lupuşoru has experience in pharmacodynamics, toxicology, biomaterial compatibility, experimental and clinical pharmacology. She has an invention patent for a polibacterial immunostimulatory agent OROSTIM with oral administration, developed an original screening for immunopharmacological studies and performed national premiere performance in immunopharmacology. She participated in the protocol design and pharmacokinetic analysis of more than 10 bioequivalence studies (1999-2004). She was or is involved in national and international grants on experimental and clinical pharmacology.
Selected achievements
1. Lupuşoru CE, Dumitrescu S, Aldea MJ, Albu E, Bredetean O, Tuluc F, Hoisie S. Oral immunotherapy in women with chronic genital infections by means of a new microbial immunomodulator. In: Masihi KN editor. Immunotherapy of infections. New York: Marcel Dekker, 1994, 371-381.
2. Invention patent for a polibacterial immunostimulatory agent OROSTIM with oral administration (co-author)
3. Radu CD, Salariu M, Avadanei M, Ghiciuc C, Foia L, Lupuşoru EC, Ferri A, Ulea E, Lipsa F. Cotton-made cellulose support for anti-allergic pijamas. Carbohydr Polym. 2013 Jun 5;95(1):479-86.
Dr. Cătălina Elena Lupuşoru is a active member of the following scientific associations: The Society of Physicians and Naturalists, Iasi, Romania; Therapeutics, Pharmacology and Clinical Toxicology Romanian Society; Therapeutics, Pharmacology and Clinical Toxicology European Society; Romanian Society of Cell Biology; Romanian Society of Biomaterials, International Association for the Study of Pain and Balkan Medical Union.
Lecturer PhD Gratiela Popa – received her PhD in 2006 in Pharmaceutical Technology at University of Medicine and Pharmacy “Grigore T. Popa” from Iasi. Her recent research career focuses on:
-Technology of solid dosage forms: formulation, preparation and quality control of conventional tablets, orally disintegrating tablets;
– Granulation techniques (wet granulation, melt granulation) with innovative binders.
– Management of pain with new combinations of analgesic drugs (binary, ternary combinations), formulated into orally disintegrating tablets.
Lecturer PhD Raoul Lupușoru – is employed in the project as Postdoctoral researcher
32 years, MD, PhD, Teaching assistant – Pathophysiology, First Department, Faculty of Medicine, “Gr. T. Popa” University of Medicine and Pharmacy, Iaşi.
Dr. Raoul-Vasile Lupuşoru received his MD in 2007 and his PhD in 2012, in Normal and Pathological Physiology, from “Gr. T. Popa” University of Medicine and Pharmacy, Iaşi, Romania. As an undergraduate student and PhD student at the same university, he worked in two research groups (in the Department of Pathophysiology and in the Department of Pharmacology). He has been an assistant at Department of Pathophysiology, “Gr. T. Popa” University of Medicine and Pharmacy, Iaşi, Romania since 2013. Dr. Raoul-Vasile Lupuşoru has experience in biomaterial compatibility (including nanomaterials), nanotoxicology, and experimental pathophysiology (animal models of diabetes, ultraviolet irradiation). He was involved in national grants investigating novel molecules and biomaterial compatibility.
Projects (Title, Type, Nr, Capacity, Funding source, Period)
* Phenothiazine hybrids – heterocultures containing nitrogen and sulfur atoms with potential pharmacological effects, CEEX, Nr. 682/2006, member, National Authority for Scientific Research, Romania, 285.654 lei („Gr. T. Popa“ University of Medicine and Pharmacy, Iaşi), 2006-2008.
* Nanostructured materials for surface functionalization of joints endoprostheses with reduced wear, PC – Research and Development Complex Projects, Nr. 72180, 01/10/2008, member, UEFISCDI, Romania, 53.260 lei („Gr. T. Popa“ University of Medicine and Pharmacy, Iaşi), 2008-2011.
* Research on the use of pharmacogenomic and pharmacokinetic investigations for tuberculosis therapy individualization in special clinical situations, PC – Research and Development Complex Projects, Nr. 42148, 01/10/2008, member, UEFISCDI, Romania, 241.488 lei („Gr. T. Popa“ University of Medicine and Pharmacy, Iaşi), 2008-2011.
* Absorbable implants made of biomimetic biomaterials used in arthroscopy, PC – Research and Development Complex Projects, Nr. 72192, 01/10/2008, member, UEFISCDI, Romania, 94.008 lei („Gr. T. Popa“ University of Medicine and Pharmacy, Iaşi), 2008-2011.
* Pharmacological influence on nociception by analgesics integrated into original nanoparticulate systems, „Gr. T. Popa“ University of Medicine and Pharmacy Internal Grant, Nr. 16407/2009, member, „Gr. T. Popa“ University of Medicine and Pharmacy, Iaşi, 21.500 lei, 2009-2010.
* Updates in Romanian nanomedicine research, PN-II-RU-MC-2008-2, Nr. 49 / IX 2008, manager, UEFISCSU, Romania, 7.000 lei („Gr. T. Popa“ University of Medicine and Pharmacy, Iaşi), 2008.
Selected papers
1. Mititelu Tartau L, Popa EG, Lupusoru RV, Lupusoru CE, Stoleriu I, Ochiuz L. Synergic effects of pregabalin-acetaminophen combination in somatic and visceral nociceptive reactivity. Pharmacology. 2014; 93(5-6):253-259
2. Lupuşoru RV, Zamfir C, Lupuşoru CE, Gafiţeanu C, Marinescu M, Bădescu M. The protective effects of some vegetable active principles in animals exposed to ultraviolet radiation, Revista Română de Anatomie Funcţională şi Clinică, Macro şi Microscopică şi Antropologie, 2011, Vol. X, Nr. 3, pp. 313-316, ISSN 1583-4026,
3. Tarţău L., Lupuşoru R.V., Andriţoiu C., Melnig V., Experimental researches on the effects of tramadol soft matter vesicles in nociceptive processes in mice, Ann. Rom. Soc. Cell Biol., 2011, Vol. XVI, Issue 1, pp. 194-198. ISSN 1583-6258
4. Gavăt C, Ghiciuc CM, Zamfir CL, Lupuşoru RV, Lupuşoru CE. , Research on immune system response, skin and hepatic reactivity in laboratory animals after retro-auricular topical administration of two reactive textile dyes, Rev Med Chir Soc Med Nat Iasi. 2010 Apr-Jun;114(2):510-4.
5. Tartau L, Lupusoru RV, Bindar D, Melnig V. Experimental research on the effects of nanovesicles encapsulating ketoprofen in a visceral pain model in mice. Therapeutics Pharmacology and Clinical Toxicology. 2010; 14(2):113-116
6. Tarţău L., Şindrilar E.V., Lupuşoru R.V., Lupuşoru C.E., “The effects of certain serotonin 5HT3 subtype receptor antagonists in a visceral pain model – experimental data”, Ther. Pharmacol. Clin. Toxicol., Vol. XIII, No. 2, 2009, pp. 167-171.
Dr. Raoul-Vasile Lupuşoru is an active member of the following scientific associations: Romanian Pathophysiology Society, Romanian Society of Cell Biology, Romanian Society of Biomaterials, Romanian Society of Morphology, European Society for Nanomedicine, Balkan Medical Union. His work was awarded several congress prizes, Excellency Scholarships (2004-2005 and 2005-2006), BRD Academic Scholarship – Groupe Société Générale 2007 and Excellency Prize (at “Student of the Year” Contest, Bucharest, 2007).
Lecturer Phd Cristina Ghiciuc– is a key person of Partner P1. She has experience in clinical pharmacology, pharmacokinetics, toxicology, biomaterial compatibility, experimental pharmacology. She participated in the protocol design and pharmacokinetic analysis of more than 20 bioequivalence studies (1999-2004). She was or is involved in national grants on experimental and clinical pharmacology. She is a member of several scientific societies, such as: SMN – European Society of Clinical Pharmacology and Therapeutics, National Society of Cellular Biology, The Romanian Society of Physicians and Naturalists.
Three of her most important achievements in the topic of the project area:
1. Radu CD, Salariu M, Avadanei M, Ghiciuc C, Foia L, Lupusoru EC, Ferri A, Ulea E, Lipsa F. Cotton-made cellulose support for anti-allergic pajamas. Carbohydr Polym. 2013 Jun 5;95(1):479-86.
2. Bercea RM, Patacchioli FR, Ghiciuc CM, Cojocaru E, Mihaescu T. Serum testosterone and depressive symptoms in severe OSA patients. Andrologia. 2012; 1-6 [ISI Web of Knowledge, in process]
3. Ghiciuc CM, Cozma-Dima CL, Pasquali V, Renzi P, Simeoni S, Lupusoru CE, Patacchioli FR. Awakening responses and diurnal fluctuations of salivary cortisol, dhea-s and α-amylase in healthy male subjects. Neuro Endocrinol Lett. 2011;32(4):475-80.
Lecturer PhD Alina Ștefanache – is associate professor with the Department of Inorganic Chemistry of the “Grigore T. Popa” University of Medicine and Pharmacy of Iasi, Romania. She obtained a PhD degree in Pharmaceutical Science in 2002 at the “Grigore T. Popa” University of Medicine and Pharmacy of Iasi, Romania.
Fields of expertise:
– synthesis and pharmacological study of some complexes;
– obtaining by synthesis, semisynthesis and biosynthesis of new biologically active derivatives;
– qualitative and quantitative analysis of pharmaceuticals belonging to different therapeutic classes;
– physico-chemical analysis of pharmaceuticals.