FACULTY OF CHEMISTRY

MATERIALS CHEMISTRY GROUP

Research Interests:

 *Nano – and biomaterials: synthesis, characterization and use in photocatalysis / environmental protection;

*Oxidic nanoporous, ordered materials for use in adsorption (photo)catalysis, sensors and ionic exchange.

*Mesoporous carbon materials: synthesis, characterization and applications;

*Design of silica-based  drug delivery systems;

*Innovative topical formulations for skin-directed therapy of Cutaneous T-cell Lymphoma.

 Equipments:

* Spectrophotometer UV-VIS, Schimadzu UV-24101PC, equipped with diffuse reflectance accessories for solid and liquid analysis;
*Quantachrome NOVA 2200^e Instrument & Pore Size Surface Area Analyzer;
*Spectrometer AAS model ContrAA 300, AnalytikJena;
*TOC analysis device AnalytikJena;
*Sonics Vibra cell ultrasonic device CV33 (High Intensity ultrasonic liquid Processors);
*UV-VIS device for liquid SPECTRO SC (Single Beam Spectrophotometer);
*Calcination oven (up to 1100 ° C);
*Pyrolysis oven with controlled atmosphere;
*Photocatalysis reactor (UV and visible);
*Water purificator PureLab Option, ELGA;
*Drying stove with controlled atmosphere, LabTech;
*Ultratermostating Device with stirring Heidolph MR Standard up to 300 °C, 1400 rpm;
*Centrifuge working up to 4000 rpm;
*Analytical balance

Team: 

Prof. univ. dr. Aurelia Vasile – Collaborator (1.08.2014-1.02.2015), 

Scientific manager (1.02.2015-9.11.2015); 

Project Manager (9.11.2015-31.12 2016)

Professor Aurelia Vasile was part of the teaching staff at the Faculty of Chemistry, “Alexandru Ioan Cuza” University from Iasi for 36 years. She has very good expertise in synthesis, characterization and applications of nanoporous materials such as synthetic and natural zeolites, ordered mesoporous materials, synthesis of metal, oxides or calcogenide nanoparticles inside nanoporous matrix. Over the years she has published over 50 articles in ISI indexed scientific journal and 3 monographs in the research topic of materials development with special properties tuned for specific applications, 24 national patents on innovative procedures of synthesis and application of nanoporous zeolitic materials. More, she has tutored or co-tutored many students in obtaining their licentiate diploma, Master diploma or PhD degree. Professor Aurelia Vasile successful managed the post-doc research work performed by Dr. A.M. Tomoiaga within the POSDRU/89/1.5/S/63663 2007-2013 project on development of core-shell magnetic mesoporous nanoparticles for targeted delivery and controlled release of chemotherapeutics. Also, she has tutored another postdoc research realized by Dr. M. Ignat, on Innovative use of mesoporous carbon materials for photocatalytic activity enhancement of semiconductor oxides. Composites for waste water depolution.

Publications :

1. A. Vasile, M. Ignat, A.M. Tomoiaga, Novel Functionalities of Mesoporous Molecular Sieves to Extend Their Applications in Emerging Fields in “Comprehensive guide for Mesoporous Materials. Volume 2. Analysis and Functionalization, Mahmood Aliofkhazraei Editor, chapter 15, p 351-373, Nova Science Publishers, New York, 2015

2.  A.M. Tomoiaga,  A. Vasile, M. Alexandroaei, I. Sandu, Ultrasound-assisted rapid growth of water compatible magnetite nanoparticles, Journal of Optoelectronics and Advanced Materials, 1 – 2, 2014, 221 – 226.

3. Alina Maria Tomoiaga, Lacramioara Ochiuz, Aurelia Vasile, Sonochemical development of nanoparticulate magnetic therapeutic systems as 5-fluorouracil carriers, Journal of Nanotechnology in Diagnosis and Treatment, 2013, 1, 11-18.

4. Alina Maria Tomoiaga, Bogdan Ionel Cioroiu, Valentin Nica, Aurelia Vasile, Investigations on nanoconfinement of low-molecular antineoplastic agents into biocompatible magnetic matrices for drug targeting, Colloids and Surfaces B: Biointerfaces, Volume 111, 1 November 2013, Pages 52-59.

5. A. Vasile, A. M. Busuioc-Tomoiaga, A new route for the synthesis of titanium silicalite-1, Mater. Res. Bull. 47 (2012) 35–41;doi:10.1016/j.materresbull.2011.10.008.

6. I. Ursachi, A. Vasile, A.Ianculescu, E. Vasile, A. Stancu, Ultrasonic-assisted synthesis and magnetic studies of iron oxide/MCM-41nanocomposite, Mat. Chem. Phys. 130 (2011) 1251–1259, doi:10.1016/j.matchemphys.2011.09.004.

7. I. Ursachi, Al. Stancu, A. Vasile, Magnetic α-Fe₂O₃/MCM-41 nanocomposites: Preparation, characterization, and catalytic activity for methylene blue degradation, J. Colloid Interf. Sci. 377 (2012) 184-190,doi.org/10.1016/j.jcis.2012.03.066.

8. I. Ursachi, A. Vasile, H. Chiriac, P. Postolache and A. Stancu, Magnetic properties of magnetite nanoparticles coated with mesoporous silica by sonochemical method, Materials Research Bulletin, Volume 46, Issue 12, December 2011, Pages 2468-2473.

9. A.M. Busuioc,R. DeMondt, H. Moisio, P. Cool, A. Vasile, N. Bilba, E.F. Vansant and L.VanVaeck, Complementary use of Fourier Transform Laser Microprobe Mass Spectrometry (FT LMMS) and Time-of-Flight Static Secondary Ion Mass Spectrometry (S-SIMS) for the study of the surface adsorption of organic dyes on silicate materials, Rapid Comm. Mass Spectrom., 19, 2005, 2809.

 

Dr.chim. Alina Maria Tomoiagă – Project Manager (1.08.2014 – 12.10.2015)

Dr. Alina Tomoiagă has good expertize in the field of applied nanotechnologies, particularly towards the development of nanomaterials with special designed properties for specific applications in priority areas such as environment and biomedicine treatment. She developed a career in chemistry taking advantage of every opportunity to improve her knowledge and skills, specifically  in applied nanotechnology  and analytical chemistry. The papers published in prestigious international journals and participation in various national and international conferences are proof of the excellent results obtained in the length of doctoral and post-doctoral research carried out in Belgium and Romania. Currently, her area of ​​expertise lies on the border between nanotechnology and biomedicine, her research activity being devoted to the development of new therapeutic nanoparticulate delivery systems targeted and controlled release of pharmaceutically active compounds. Also she is dedicated for easy transfer of results of research in the productive sector. Few of her representative published works are:

1. A. Vasile, A.M. Tomoiagă*, M. Ignat, Novel Functionalities of Mesoporous Molecular Sieves to Extend Their Applications in Emerging Fields in “Comprehensive guide for Mesoporous Materials”, Volume II, M. Aliofkhazraei (ed.), ISBN: 978-1-63463-982-8 (Print); 978-1-63463-991-0 (e-book), Nova Science Publishers, New York, USA, 2015, p. 351- 373.

2. L. Ochiuz, A. Vasile, B. I. Cioroiu, A. M. Tomoiaga, Comparative study on immobilization of mechlorethamine on inorganic biocompatible nanoporous carriers, SGEM2015 Conference Proceedings, ISBN 978-619-7105-42-1/ISSN 1314-2704, June 18-24, 2015, Albena, Bulgaria, Book 6 Vol. 1, p.25-39. DOI: 10.5593/SGEM2015/B61/S24.004

3. B.I. Cioroiu, M.E. Cioroiu, D. Tarcău, A.M. Tomoiagă, M.I. Lazăr, Determination of PAHs in lung tissue samples using specific chromatographic techniques: method development and validation, Journal of Liquid Chromatography and Related Technologies, 37, 5, 2014, 713 – 725.

4. A.M. Tomoiagă, L. Ochiuz, A. Vasile, Sonochemical development of nanoparticulate magnetic therapeutic systems as 5-fluorouracil carriers, Journal of Nanoechnology in Diagnosis and Treatment, 1, 2013, 26 – 35.

5. A.M. Tomoiagă, B.I. Cioroiu, V. Nica, A. Vasile, Investigations on nanoconfinement of low-molecular antineoplastic drugs into biocompatible magnetic matrices for drug targeting, Colloids and Surfaces: Biointerfaces, 111, 2013, 52 – 59.

6. L. Ochiuz, G. Popa, G. Lisa, A.M. Tomoiagă*, M. Popa, Microencapsulation of metoprolol tartrate into chitosan for improved oral administration patients compliance, Industrial & Engineering Chemistry, 52, 2013, 17432 – 17441.

7. K. De Witte, A.M. Busuioc, V. Meynen, M. Mertens, N. Bilba G. Van Tendeloo, P. Cool and E.F. Vansant Influence of the synthesis parameters of TiO2-SBA15 materials on the adsorption and photodegradation of rhodamine 6G, Micro and Mesoporous Materials, 110, 2008, 100 – 110

8. A.M. Busuioc*, V. Meynen, E. Beyers, M. Mertens, P.Cool, N. Bilba and E.F. Vansant, Structural features and photocatalytic behaviour of titania deposited within the pores of SBA-15 by filling with colloidal dispersion, Applied Catalysis A: General, 312, 2006, 153 – 164.

9. A.M. Busuioc*, R. DeMondt, H. Moisio, P. Cool, A. Vasile, N. Bilba, E.F. Vansant and L.VanVaeck, Complementary use of Fourier Transform Laser Microprobe Mass Spectrometry (FT LMMS) and Time-of-Flight Static Secondary Ion Mass Spectrometry (S-SIMS) for the study of the surface adsorption of organic dyes on silicate materials, Rapid Communications in Mass Spectrometry, 19, 2005, 2809

 

Conf. dr. Maria Alexandroaei – Senior Researcher (1.10.2014-12.02.2015)

Degree in Chemistry, Faculty of Chemistry, “Alexandru Ioan Cuza” University  from Iasi, 1973 promotion, diploma nr. 150060 / 17739 / 18.IV.1974. PhD in Chemistry, Materials Science Specialty, confirmed by the Order of The National Education  Minister, no. 3772 from 5.05.1999.

 –   Topics in research: Synthesis, characterization and use of zeolite materials and  biomaterials. Characterization of drugs and cosmetics. She contributed at solving the following research topics: (1) “Microporous crystalline solids with specific role of adsorbent or catalyst; (2) “Applications of zeolite materials in catalytic processes” ; (3) “Oxide compounds performers to protect the environment”;(4) “Multifunctional porous oxide materials for the retention and the degradation of the hazardous substances from water”; (5) “New technology of the uranium separation, solvent  extraction, in an ultrasonic field, with a positive impact on the reduction of the  uranium concentration in the area surrounding”.

 –    Representative works: 

1. M.Alexandroaei, M.Ignat, G.I.Sandu, “The Removal of the Pb²⁺ Ions from Solutions  by a Hydroxyapatite Nanomaterial”, Chemistry Magazine, 64, (19), 1100-1105, (2013);

2. M.Ignat, M.Alexandroaei, N.C. Lungu, “The Removal of Zn²⁺ Ions from Groundwater using Hydroxyapatite Nanoparticles”, Chemistry Magazine, 62, ( 5 ), 518-521, (2011);

3. N.C.Lungu, M.Alexandroaei,  I.Sandu. “Study of the Penicillin Dissipationn Aqueous Solution of Penicillinase with Attenuated Activity”, Chemistry Magazine, 62, ( 8 ), 787-791, (2011).

Assis.univ. dr. Maria Ignat – Postdoctoral Researcher – defended her PhD in 2011 in the field of design of mesoporous carbon materials for applications in environment protection. Currently, she is employed as Assistant at the  “Alexandru Ioan Cuza” University from Iasi and her research interests are focused on design of mesoporous silica/carbon nanomaterials for specific applications in biomedicine and environmental protection. She is co-author for 6 articles published in ISI indexed journals in the biomedical field. Some of the most important publications of Dr. Maria Ignat in the field or the present project are:

1.   I.F. Alexa, C.G. Păstrăvanu, M. Ignat, E. Popvici, A comparative study on long-term MTX controlled release from intercalated nanocomposites for nanomedicine applications, Colloids and Surfaces B:Biointerfaces, 106, 2013, 135 – 139
2. I.F. Alexa, M. Ignat, R.F. Popovici, D. Tâmpu, E. Popvici, In vitro controlled release of antihypertensive drugs intercalated into unmodified SBA-15 and MgO modified SBA-15 matrices, International Journal of Pharmaceutics, 436, 2012, 111 – 119
3. M. Ignat, A. Farcas, A.  Vasile, E.  Popovici, Calixarene-modified multi-wall carbon nanotubes, Studies in Surface Science and Catalysis, 174, 2008, 389 – 392.

Dr. chim. Cioroiu Bogdan – Researcher

– graduated from “Alexandru Ioan Cuza“ University from Iasi, Faculty of Chemistry in 2003 and received his PhD at “Grigore T. Popa” University of Medicine and Pharmacy  of Iasi. Currently he manages the analytical chemistry activities within S.C. ChemPerformance S.R.L. from Iasi. Some of the most important publications of Dr. Bogdan Cioroiu in the field or the present project are:

1.  Cioroiu, BI; Cioroiu, ME; Tarcau, D; Tomoiaga, AM; Lazar, MI, Determination of pahs in lung tissue samples using specific chromatographic techniques: method development and validation, Journal Of Liquid Chromatography & Related Technologies, 37, 2014, 713 – 725
2.   Cioroiu, BI; Lazar, MI; Bello-Lopez, MA; Fernandez-Torres, R, Identification of the specified impurities of silver sulfadiazine using a screening of degradation products in different stress physico-chemical media Talanta, 116, 2013, 653 – 662.
3. Tomoiaga, AM; Cioroiu, BI; Nica, V; Vasile, Investigations on nanoconfinement of low-molecular antineoplastic agents into biocompatible magnetic matrices for drug targeting, Colloids And Surfaces B-Biointerfaces, 111, 2013, 52 – 59
4. Costin, M; Cioroiu, B; Agoroaei, L; Butnaru, E, Contribution to the development and validation of a high performance liquid chromatography by the uv detection method for isoniazid and omeprazole determination, Cellulose Chemistry And Technology, 46, 2012, 511 – 516